Search on:
MITOCHONDRIAL APOPTOSIS INDUCING FACTOR
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Apoptosis Inducing Factor
Descriptor
Spanish
:
Factor Inductor de la Apoptosis
Descriptor
Portuguese
:
Fator de Indução de Apoptose
Synonyms
English
:
AIF Apoptosis Regulatory Protein
Apoptosis-Inducing Factor
Apoptosis-Inducing Factor, Mitochondrial
Mitochondrial Apoptosis Inducing Factor
Mitochondrial Apoptosis-Inducing Factor
Tree Number:
D08.811.682.608.047
D12.644.360.075.311
D12.776.157.687.063
D12.776.331.161
D12.776.476.075.311
D12.776.660.720.063
Definition
English
:
A
flavoprotein
that functions as a powerful antioxidant in the
MITOCHONDRIA
and promotes
APOPTOSIS
when released from the
mitochondria
. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein
family
. It translocates to the
CELL NUCLEUS
and binds DNA to stimulate CASPASE-independent
CHROMATIN
condensation.
Indexing Annotation
English
:
INHIBITOR OF APOPTOSIS PROTEINS
is also available
History Note
English
:
2006(1999)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50601
Unique Identifier:
D051033
Occurrence in VHL
:
Similar:
DeCS